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KMID : 1123920080220051215
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 5 p.1215 ~ p.1222
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Antidementia Effect of Jangwonhwangagambang Water Extract in APP-induced Drosophila Model
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Kim Sang-Tae
Lee Chung-Sik
Park Bo-Ra
Jung Eun-Young
Kim Dae-Hyun
Yun Jong-Hyun
Kim Jin-Woo
Kang Hyung-Won
Lyu Yeoung-Su
Kim Tae-Heon
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Abstract
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Recent studies indicate that the deposition of -amyloid () is associated with the pathogenesis of Alzheimer’s disease (AD), but the underlying mechanism is not clear yet. To investigate the effects of Jangwonhwangagambang (JWHG) extract on AD pathogenicity, we have generated transgenic Drosophila model in which GMR-APP-GAL4/UAS-GRIM system was designed to overexpress amyloid precursor protein(APP), We examined fly’s survival ratio, flight behavior, and morphological patterns of chest and eye. We found that JWHG treatment improved fly’s survival ratio by inhibiting apoptosis and flight behavior. APP-GRIM transgenic flies treated with JWHG showed had significantly lower levels of APP deposition in the chest and eye compared to control animals. JWHG treatment further inhibited chest and eye degeneration. These results suggest that JWHG prevents APP-induced neurotoxicity, and thus may be applicable for the development of preventive or therapeutic agents for AD treatment.
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KEYWORD
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drosophila, Alzheimer’s disease, dementia, APP-amyloid, Jangwonhwangagambang(JWHG)
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